The PX domain
نویسندگان
چکیده
Q15080 p40phox Hs R 3P Ellson et al. (2001a); Kanai et al. (2001) P14598 p47phox Hs R 3,4 Ago et al. (2001); Kanai et al. (2001) O60493 SNX3 Hs R 3P Xu et al. (2001a) Q9UNH6 SNX7 Hs R 3P Xu et al. (2001a) P57768 SNX16 Hs R 3P Xu et al. (2001a) Q9BSD1 RGS-PX1 Hs R 3P Zheng et al. (2001) P32912 Vam7 Sc R 3P Cheever et al. (2001); Song et al. (2001); Yu et al. (2001) Q08826 SNX3 Sc R 3P Yu et al. (2001) Q01846 Mdm1 Sc R 3P Yu et al. (2001) P38815 Yhr105w Sc R 3P Yu et al. (2001) P29366 Bem1 Sc Y 4P Ago et al. (2001) Q9ERE3 CISK Mm R 3P/3,4,5 ? Virbasius et al. (2001); Xu et al. (2001b) Q9VTN5 CPK PI3K Mm S 4,5 Song et al. (2001)
منابع مشابه
The phox homology (PX) domain protein interaction network in yeast.
The phox homology (PX) domain is a phosphoinositide-binding domain that is conserved from yeast to human. Here we show for the first time by genome-wide two-hybrid screens and in vitro binding assays that the PX domain is a bona fide protein interaction domain. The yeast PX domain-only proteins Grd19p (YOR357C) and Ypt35p (YHR105W), as well as the isolated PX domains from Mvp1p (YMR004W), Snx42...
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Phox homology (PX) domains, which have been identified in a variety of proteins involved in cell signaling and membrane trafficking, have been shown to interact with phosphoinositides (PIs) with different affinities and specificities. To elucidate the structural origin of diverse PI specificities of PX domains, we determined the crystal structure of the PX domain from phosphoinositide 3-kinase ...
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Phox homology (PX) domains, which have been identified in a variety of proteins involved in cell signaling and membrane trafficking, have been shown to interact with phosphoinositides (PIs) with different affinities and specificities. To elucidate the structural origin of the diverse PI specificity of PX domains, we determined the crystal structure of the PX domain from Bem1p that has been repo...
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متن کاملThe crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.
More than 50 human proteins with a wide range of functions have a 120 residue phosphoinositide binding module known as the PX domain. The 1.7 A X-ray crystal structure of the PX domain from the p40(phox) subunit of NADPH oxidase bound to PtdIns(3)P shows that the PX domain embraces the 3-phosphate on one side of a water-filled, positively charged pocket and reveals how 3-phosphoinositide specif...
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Sorting nexins (SNXs) or phox homology (PX) domain containing proteins are central regulators of cell trafficking and signaling. A subfamily of PX domain proteins possesses two unique PX-associated domains, as well as a regulator of G protein-coupled receptor signaling (RGS) domain that attenuates Gαs-coupled G protein-coupled receptor signaling. Here we delineate the structural organization of...
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